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Succinic acid

Succinic acid
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Pyelonephritis Tonsillitis Bronchial asthma Cirrhosis Hangover treatment prevention Succinic acid Properties Recommendations Application buy store traditional medicine. Hypoxia Atherosclerosis Cerebral circulation treatment prevention at home by extracts of health.

Succinic acid - a product resulting from the processing of natural amber. It is absolutely harmless substance with specific useful properties. It is a white crystal-powder, to taste very reminiscent of citric acid.

Every day, our body produces about 200 g of succinic acid and he himself uses it for its own needs.


Healthy body enough of succinic acid, which he produces or receives with food. However, in adverse conditions, as a result of stress or physical exertion dramatically changed there is tension in the chain of metabolic consumption of succinic acid is increased, there is a shortage of it, and after - the feeling of fatigue and malaise. Well-being at the same time worsens, the body loses its ability to withstand adverse environmental effects, lead to abnormalities and malfunctions of various systems, develop the disease. And here we come to the aid of succinic acid.
 

Succinic acid properties.



yantarnaya_kislota_svoistvaSuccinic acid (succinate) - a substance produced in the processing of natural Baltic amber. It's completely safe product, which has a number of useful features. Was obtained as a white crystalline powder, with a similar taste of citric acid. In the body of succinic acid activated as anions and salts, succinates known.

Succinate - are natural regulators of the organism. We feel the need for them at elevated physical, psycho-emotional, intellectual loads for various diseases.

Succinic acid has a unique effect: it accumulates in those areas that need it, while ignoring healthy tissue.

Being in nature. Succinic acid in free form subbitominoznom contained in coal tars, and amber. In large quantities it is contained in the unripe berries, sugar beets, sugar cane, turnips, etc.

The contents in foods. Succinic acid is a composition of many ingredients. Its content is increased in kefir and yogurt, aged wines, cheese, rye products, brewer's yeast, oysters, etc. Large quantities of succinic acid is found in unripe gooseberries and grapes, beetroot juice, etc. The seeds of barley and sunflowers succinic acid content is 5%. Most of succinic acid contains alfalfa. However, in most products of succinic acid is not present.

Therefore, in many states succinic acid is approved for use in the food industry. Addition of succinic acid in foods not only makes them more valuable, but also prolongs its life owing to filtering and antioxidant properties.

Mechanism of action. Succinic acid is a universal intermediate metabolism, highlights the interaction of saccharides, proteins and fats in living cells. Succinates activity in the body is associated with the production of energy expended on the livelihoods of all organs and systems.

 

By increasing the load on any organ or system of the body, the energy for their work is mainly provided by the process of succinate oxidation.


Mechanism of energy using succinates running hundreds of times more effective than all other mechanisms of energy production in the body. It is through this succinic acid has a non-specific curative effect in a number of diseases of different etiology. Succinic acid also has anti-virus and antihypoxia action.

Laboratory studies have demonstrated that the use of succinic acid caused more intensive oxygen uptake by living cells. Oxidation of succinic acid is a necessary step in the process of assimilating cells diatomic oxygen.

The therapeutic effect of succinates is based on modifying the effect on cellular metabolism - cellular respiration, transport of trace elements, the production of proteins. The degree of modification depends on the specificity and the initial tissue state. As a result of these modifications are optimized operating parameters of the tissues. Scientists have proved that succinic acid and succinates are adaptogens (increase the body's resistance to adverse environmental factors).


 

Succinic acid stimulates the supply of oxygen to the cells, facilitates stress, restores energy exchange, normalizes the process of production of new cells, has a tonic and restorative properties.



gipoksiyaActivity of succinic acid in the human body is regulated by hypothalamus and adrenal glands. Restoring the balance of biochemical reactions in the body, succinate normalize the function of all organs and tissues. Particularly significant impact on their brain, which is more in need of uninterrupted delivery of oxygen and energy.

Therefore, succinic acid is used to prevent brain pathologies that develop with aging. Additionally, it recovers all the functions of the nervous system and prevents stress.

Additional consumption of succinic acid contributes to the normalization of work and other organs and systems. Heart need a constant supply of energy, otherwise it decreases contractility, which invariably leads to disruption of blood circulation, swelling and dysfunction of all organs and systems - ie, heart failure. As a result of stimulation of the liver and kidneys body more effectively cleared of toxic metabolites and other harmful agents.

Succinic acid is a common normalizes metabolism in the body. It enhances immunity through a more efficient synthesis of the cells of the immune system. Due to its antioxidant action, succinates inhibit tumor development and growth, and prevent malignant cell division.

Succinic acid decreases the production of the main mediators of inflammation and allergic reactions - histamine, which means that the symptoms of inflammatory reactions and allergy attacks. Her medications are often prescribed to neutralize certain toxins (eg, ethanol, nicotine and others.).

Succinic acid is recognized as completely harmless substance. It is able to exert a therapeutic effect, even in small quantities. It also increases the nutritional value of basic food components and increases the effect of drugs.


 

Succinic acid indications.




In diseases of the joints succinate stimulate local blood circulation, which promotes leaching of salts. They also inhibit inflammation.

Varicose veins succinic acid eliminates inflammation and normalizes the function of the venous valves. Restored normal local blood circulation, resulting in inflammation of the veins and passes restored.

Anti-inflammatory effect of succinic acid is observed at:


 

 

Also, succinic acid has a therapeutic effect in gallstone disease by stimulating the excretion of salt, breaking stones and contributing to cleanse the liver.


Succinate prevent ischemia of internal organs, help the recovery of function after ischemic injury. Succinate also useful for:

 



With a sufficient level of succinates in the mother, the probability of oxygen starvation of tissues and viral infection of the fetus during pregnancy related diseases is greatly reduced. In clinical practice, succinic acid drugs used in the treatment of cardiovascular disease, in circulatory disorders of the brain to stimulate the secretion of digestive juices, as an antidote to poisoning by arsenic, lead, mercury, and in many other situations.
 

Succinic acid helps to maintain an active lifestyle at any age.


Succinic acid is used in treatment of coronary heart disease. This is caused mainly by oxidation by activation of enzymes, including playing a role in the mitochondrial oxygen. Normalization of metabolism in the heart and restoration of coronary blood flow causes antiarrhythmic effects succinates.

Before using the product of succinic acid are strongly advised to obtain medical advice.

 

Succinic acid Dosage and administration.



yantarnaya_kislota_primenenieCourse is recommended to start with 500 mg succinates every day in the morning after breakfast. While improving the well-being and sleep normalization dose should be reduced to 250-100 mg. In this technique can be divided by 2-3 times (although it is recommended to use succinic acid in the minimum necessary dose).
 

Often patients can, assessing their emotional status, succinates choose individual dose required to maintain the vitality and wellness.


During the course of the use of succinic acid on certain days you must take appropriate breaks (eg, 1-2 days break every 3 days for reception). Such a preparation method allows to extend the application rate and hence the effect, whereas at higher doses the daily use of the duration of treatment does not exceed 10 days.

In the absence of subjective symptoms action succinates dosage should be increased, taking 500 mg of 2 reception (in the morning). In special cases, the dose can be increased to 3000 mg per day. Such cases arise in the application of succinic acid in combination with other drugs. After high physical activity is recommended to take a single dose of 3000 mg.

Increased dosage succinates expedient catarrhal inflammation radiculitis skeletal muscle (1000 mg 3-4 times a day, 3-7 days). During exacerbation of heart failure expedient introduction of succinic acid 30-40 mg per kilogram per day.


 

What is the secret of succinic acid.


Cellular processes that are driven by all living things.


Accepted dietary carbohydrates, fats and proteins are broken down into simple compounds - glucose, glycerol, fatty acids and amino acids, which in energy exchange reactions occurring within the cells, are converted into organic acids and then oxidized to carbon dioxide and water. Glucose and glycerol is first oxidised anaerobically, i.e. without oxygen, in enzymatic reactions, known as glycolysis.

In those situations where the oxygen supply is not sufficient to ensure the functional load (job) of energy, the activation of anaerobic glycolysis in tissues and accumulates the final product of glycolysis - lactic acid (lactate). In all living cells - whether animal or plant cells, fungi or bacteria - contains special calf few microns in size, which are called mitochondria. In the mitochondria mainly generated and used for subsequent reactions succinic acid.

If sufficient oxygen supply all organic acids are burned in specialized organelles - the mitochondria due to consumption of oxygen from the air. Under aerobic conditions, the products of glycolysis, oxidation of fatty acids and amino acids are burned - oxidized with oxygen in the mitochondria - cellular organelles that act as the main source of energy. Accumulation occurs in the respiratory chain - multienzyme complex in the mitochondrial membrane.


 

Energy metabolism in cells.



Most of the energy of the sun encased in chemical bonds with the food we consume substances released during the oxidation of organic acids in the cyclic sequence of reactions opened by Sir Hans Krebs. Whatever the substance nor were the original fuel (proteins, fats, carbohydrates), they are converted into organic acids of the Krebs cycle.

Krebs cycle, respiratory chain and energy storage system located in the mitochondria. Mitochondria are called power plants of the cell. It occurs in the mitochondria burn all kinds of substances, the mitochondria supply ATP as a universal energy fuel for all types of work and synthesis in the body tissues. The quantity and quality of mitochondria their function and interaction with glycolysis and oxygen delivery system determine the range of the cell and the functional activity of the corresponding tissue.


 

Succinic acid in the energy.



yantarnaya_kislota_deistvieIn the normal sequence of reactions in the mitochondria - in the Krebs cycle - Succinic acid is one of the intermediates. As research professor at the Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, MN Kondrashova, energy capacity of the process of ATP synthesis in the oxidation of succinic acid is much higher than in the oxidation of any other substrate.

That is why many volatile, i.e. energy consuming processes, such as the accumulation of calcium ions, and ensuring biosyntheses hydrogen, even in isolated mitochondria can move only in the oxidation of succinic acid. School work MN Kondrashova shown that exist in nature and, if necessary, activate additional pathways of succinic acid. In particular, such an additional "injection" succinic acid occurs in a healthy person under heavy use and in recovery after stress, especially when high demand for rapid reproduction of ATP.


 

But not only high energy capacity of oxidation of succinic acid makes her give preference to other substrates.



The fact that any sufficiently intense stress develops so-called working hypoxia when oxygen consumption in the energy exchange reactions exceeds the capacity of delivery to the cells.
 

Almost all diseases of the cardiovascular system, lungs, a variety of blood diseases, poisoning, after drinking alcohol and some drugs is broken or delivery, or use of oxygen. In other words, since hypoxia.


Under hypoxia, mitochondrial respiratory chain can not take on any of hydrogen or other substrate except succinic acid. Indeed, when it is supplied to the hydrogen oxidation is significantly closer to the oxygen portion of the respiratory chain. At the same time on the site, even when deep hypoxia retained the ability to make hydrogen. In this case, succinic acid oxidation in mitochondria is one of the few sources of ATP. Additional income of succinic acid can greatly help functioning of the body.

That succinic acid, which is formed in the mitochondria, and there combusted instantaneously, so current - Fixed concentrations present in the tissues of succinic acid is not more than one time in 10-20 mg / kg of tissue, and usually does not go out of the mitochondria. Regardless of mitochondria cells is in its bloodstream almost none. It appears outside of mitochondria during heavy anaerobiosis (complete absence of oxygen) or hypoxic deep in some tissue site.

Receptor control system of the body in the bloodstream evaluate the appearance of succinic acid as a signal that in some part of the body does not have enough energy or there is lack of oxygen.

Accordingly, the body responds to this signal changes in the neuroendocrine, hormonal regulation, improvement of peripheral blood flow, enhance the strength of heart contractions, relief oxygen release by oxyhemoglobin and a number of other physiological and biochemical compensatory reactions.

This reaction mobilization of energy metabolism. And they do not occur in response to hypoxic The onset of actual energy deficit. A signal to that, it may take place. Absolutely harmless succinic acid and its ability to have a positive effect even at low doses, increase the effects of drugs makes it very valuable dietary supplement.

 

The use of such additives promotes the normalization of the body.


Shelf life: 2 years.

Volume: 100 g.



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